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February 2022 Update: Auto-add our report to any ticket, huge QOL additions, PLUS, win a year of free service!

by February 9, 2022

Happy New Year, Partners! 

Our General Availability build is now v1.1.x.26, and we have a slew of stellar features to run through with you, so hold on to your seats, we’re gonna go fast:  

  • We’re official! Tier2Tickets/Helpdesk Buttons is now officially patented. So many of you supported us and saw the vision we had since our early days. Now, we have just one more point of pride, and we wanted to share with the people who have been with us every step of the way. 
  • Enter to win a year of free service for up to 10k endpoints. We’re raffling away a free year of service* to a lucky MSP who joins us for our first Tier2Tuesday Partner Panel on Tuesday, March 1, 2022 at 1PM. We’ll be joined by Chad McDonald of ITPartners+, Ian Richardson of Richardson & Richardson Consulting, and Brent of iTech Las Vegas. Register for your seat (and raffle ticket!) today, and get ready to chat with our partners as they talk about what has made them successful in implementing Tier2Tickets/Helpdesk Buttons and how that could translate to your team! *Terms and Conditions 
  • NEW Auto-add Report to ANY Ticket, regardless of source. For ConnectWise Manage, Autotask, and Syncro, if you have Configurations/Configuration Items/Assets set up, we can now append our Diagnostic Report automatically, no matter if the ticket was made with an email, phone call, a technician, or other automation. This has huge implications for our partners using DeskDirector or CloudRadial – your users can keep putting in tickets the same way you trained them, just solve them faster and with less guesswork. (Also, if you missed it, you can pull these Reports on Demand as of v1.1.x.24 as well!) 
  • NEW MSI Registry update: Create URLs to launch Tier2Tickets. Perfect for your website or launching from a User Portal. Thanks to Greg over at AlwaysOnIT for inspiring this feature! 
  • Billing Updates. We have to be honest, billing is the least interesting thing we do, it’s so boring the team would rather give the product away than build features for it. That said, we apologize for the delay: a ton of you have asked for better feedback and visibility on Billing and Licensing so we’ve updated our system.  
    • Set up your own Billing email Permissions. Emails given Billing Permissions on Subaccounts page will now receive Billing or Licensing Update Emails 
    • Email sent on License Overage. No longer do you need to keep an eye on the licensing page, we’ll send you an email when your installs exceed your licenses so you can update your licensing and ensure your technicians are still able to review our self-diagnosing Report.  
    • Email sent on Bill/Invoice Created. For your records, you will now receive an Invoice whenever your credit card has been billed, whether for monthly service or prorated for newly-added licenses.  
  • Account QOL Updates. Better logging, permissions, and in-account actions. Read them all here.  
  • NEW Loginwith.me. preview You’ll notice that anywhere you saw TechConnect, we’ve now updated those to use Loginwith.me. Loginwith.me is our answer for the remote connection capabilities where TechConnect was a tech demo of those features, Loginwith.me is already much improved and will have some features no other remote tool has. It is still in early Alpha with many of those features no yet available. As is our M.O., we wholeheartedly invite you to test it out and send us feedback at support@tier2.tech. This product will be free for commercial use and also included in Tier2Tickets licensing at no extra charge as a commitment to our goal of creating powerful tools and workflows for you and your technicians.  
  • NEW Known Issues page. Following a Geekcast with Kyle Spooner and Ray Orsini, we were inspired to create a Known Issues page as a commitment to transparency. This, coupled with our Trello Roadmap is another iteration to intentionally better outline Feature Requests and our progress on them.  

That’s it for today. Please register for our Tier2Tuesday on March 1st (even if you can’t make it, it’ll be recorded!).  

Tier2Tech 
sales@tier2.tech 

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1,145 thoughts on “February 2022 Update: Auto-add our report to any ticket, huge QOL additions, PLUS, win a year of free service!”

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    Additionally, understanding the recommended dosage and contemplating potential unwanted effects is important to prevent antagonistic health penalties. In this section, we will discuss alternate options to Dianabol, similar to non-steroid dietary supplements and comparisons with different anabolic steroids. This will provide you with a better understanding of the different options and the way they influence your physique. It’s crucial for people contemplating utilizing Dianabol to weigh these unwanted effects in opposition to the potential benefits and seek the advice of a medical skilled before starting any cycle. A widespread thread among customers is an emphasis on the significance of correct diet and training routine when utilizing Dianabol. These components, in conjunction with responsible steroid utilization, may help optimize features and decrease potential unwanted effects. Another skilled bodybuilder who shared his experience is featured in a classic video, discussing his personal journey with a Dianabol different complement.
    Whereas there are individuals who take up to 50 mgs, they’re properly into the extreme unwanted effects space. Dianabol outcomes before and after are pretty spectacular, with most individuals gaining lbs (4,5-) in 4-6 weeks. For someone who has by no means taken Dianabol earlier than, it will be sensible to run a Dianabol-only cycle before stacking it with different steroids so the physique can turn into accustomed to Dianabol first.
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    In reality, seasoned bodybuilders don’t use Dianabol alone. They use it with different steroids that it enjoys a synergy with so that the weight gained wouldn’t be misplaced easily. Anabolic steroids are synthetic substances that mimic the effects of pure testosterone. They promote muscle progress and enhance physical performance. How a lot muscle you’ll acquire may even depend on the dose, what quantity of weeks you cycle for, if you mix steroids collectively in a stack, your food plan, workouts, and your genetics. Nonetheless, these are commonplace gains for a first-time cycle. Designed that will help you build lean muscle mass and probably even help with fat loss, D-BAL is a real game changer to anybody trying to degree up.
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  239. Sermorelin and Ipamorelin are two of the most frequently discussed peptides in the realm of anti-aging and performance enhancement. Both work by stimulating growth hormone release from the pituitary gland, yet they differ markedly in their molecular structure, potency, duration of action, and side-effect profile. Understanding these nuances is essential for anyone considering peptide therapy as a means to improve healthspan or athletic recovery.

    Table of Contents

    Introduction to Peptide Therapy

    Sermorelin vs Ipamorelin: Which Peptide Therapy Is Best?

    Sermorelin – An In-Depth Overview

    Ipamorelin – An In-Depth Overview

    Comparative Pharmacology and Mechanisms of Action

    Clinical Applications and Therapeutic Indications

    Dosage Regimens, Administration Routes, and Timing

    Side Effects, Safety Profile, and Contraindications

    Cost Considerations and Accessibility

    Practical Tips for Safe Use

    Conclusion

    1. Introduction to Peptide Therapy

    Peptides are short chains of amino acids that can mimic or enhance the function of naturally occurring hormones. In the context of growth hormone (GH) stimulation, two peptides have risen to prominence: Sermorelin and Ipamorelin. Both are synthetic analogues designed to bind the growth hormone-releasing hormone receptor (GHRH-R), thereby triggering a cascade that culminates in GH release.

    2. Sermorelin vs Ipamorelin: Which Peptide Therapy Is Best?

    Choosing between Sermorelin and Ipamorelin hinges on several factors:

    Potency and Duration: Ipamorelin is generally considered more potent, requiring smaller doses to achieve comparable GH stimulation. It also has a slightly longer half-life.

    Side-Effect Profile: Sermorelin’s side effects are largely limited to mild injection site reactions, whereas Ipamorelin can occasionally provoke nausea or flushing in sensitive individuals.

    Cost and Availability: Sermorelin is often less expensive because it is available as an older formulation. Ipamorelin, being newer, may command a higher price but offers a more favorable dosing schedule for some users.

    Regulatory Status: Both peptides are not approved by major regulatory bodies for anti-aging use; they remain investigational or are sold as research chemicals. This limits their legal availability in many jurisdictions.

    Ultimately, the “best” peptide is highly individual. Those seeking a lower cost and simpler dosing may lean toward Sermorelin, while users desiring maximal GH release with minimal dosing might prefer Ipamorelin.

    3. Sermorelin – An In-Depth Overview

    Sermorelin is a synthetic decapeptide that closely resembles the first ten amino acids of natural growth hormone-releasing hormone (GHRH). Its primary function is to bind the GHRH receptor on pituitary somatotroph cells, triggering endogenous GH secretion.

    1 Molecular Structure and Synthesis

    Sequence: His-Pro-Gln-Trp-Ala-Ser-Lys-Asn-Tyr-Leu

    The peptide is chemically synthesized via solid-phase synthesis techniques. It is typically provided in a lyophilized powder form that requires reconstitution with sterile water before injection.

    2 Pharmacodynamics

    Receptor Binding: Sermorelin exhibits high affinity for GHRH receptors, but its activity diminishes after about one hour due to rapid metabolism by peptidases.

    GH Release Pattern: The peptide induces a pulsatile GH surge that mimics the natural circadian rhythm. Peak levels are usually reached within 30 minutes of injection.

    3 Pharmacokinetics

    Half-Life: Approximately 20–30 minutes when administered subcutaneously.

    Metabolism: Rapid hydrolysis in plasma; primarily cleared by renal excretion of breakdown products.

    Elimination: No significant accumulation occurs with standard dosing.

    4 Clinical Uses and Evidence

    While Sermorelin is not approved for anti-aging, it has been used clinically to treat growth hormone deficiency in children and adults. Studies have shown improvements in lean body mass, bone density, and quality of life when used appropriately.

    4. Ipamorelin – An In-Depth Overview

    Ipamorelin is a hexapeptide that mimics ghrelin’s action on the GHRH receptor but with greater selectivity for GH release over prolactin or cortisol stimulation.

    1 Molecular Structure and Synthesis

    Sequence: His-Pro-Gly-Asp-Trp-Met

    The peptide is synthesized using similar solid-phase methods, then formulated as a freeze-dry powder requiring reconstitution before use.

    2 Pharmacodynamics

    Receptor Binding: Ipamorelin has a higher affinity for the GHRH receptor and exhibits minimal cross-reactivity with other hormone receptors.

    GH Release Pattern: It produces a robust GH pulse that can last up to two hours, providing sustained stimulation.

    3 Pharmacokinetics

    Half-Life: Approximately one hour when injected subcutaneously.

    Metabolism: Degraded by peptidases but at a slower rate than Sermorelin.

    Elimination: Primarily renal; no significant bioaccumulation.

    4 Clinical Uses and Evidence

    Ipamorelin has been investigated in clinical trials for its potential to enhance muscle recovery, improve bone density, and aid weight management. Its selective action reduces the likelihood of side effects associated with other peptide analogues.

    5. Comparative Pharmacology and Mechanisms of Action

    Both peptides activate the same receptor but differ in their kinetics:

    Sermorelin’s short half-life necessitates multiple daily injections to maintain steady GH levels, whereas Ipamorelin’s longer action can often be achieved with a single dose.

    The amplitude of GH release is generally higher with Ipamorelin per milligram administered.

    Because Sermorelin closely mimics natural GHRH, it may better preserve the circadian rhythm of hormone secretion.

    6. Clinical Applications and Therapeutic Indications

    1 Growth Hormone Deficiency

    Both peptides are used off-label to treat GH deficiency in adults and children when recombinant GH therapy is unsuitable.

    2 Anti-Aging and Performance Enhancement

    Athletes, bodybuilders, and older adults sometimes use these peptides to increase lean muscle mass, reduce fat stores, improve sleep quality, and enhance recovery. Scientific evidence for long-term benefits remains limited.

    7. Dosage Regimens, Administration Routes, and Timing

    Peptide Typical Dose Frequency Route

    Sermorelin 0.2–0.5 mg Once or twice daily Subcutaneous (SC)

    Ipamorelin 0.1–0.3 mg Once daily (often before sleep) SC

    Timing Tips:

    Injections taken before bedtime can align GH release with natural nocturnal peaks.

    Avoid injecting within two hours of a meal to reduce the risk of nausea.

    8. Side Effects, Safety Profile, and Contraindications

    1 Common Adverse Events

    Injection site reactions (pain, swelling).

    Mild headache or dizziness.

    Transient flushing or nausea (more common with Ipamorelin).

    2 Rare but Serious Risks

    Excessive GH release can lead to insulin resistance or edema.

    Potential for tumor growth stimulation in susceptible individuals.

    3 Contraindications

    Known hypersensitivity to peptide components.

    Active malignancy, uncontrolled diabetes, or severe cardiovascular disease.

    9. Cost Considerations and Accessibility

    Sermorelin is often available at a lower price point due to its older formulation; typical costs range from $50–$100 per month for a standard dose. Ipamorelin tends to cost between $80–$150 monthly, reflecting its newer status and higher potency.

    Legal availability varies by country: many nations restrict sale to research use only. Users must ensure compliance with local regulations before procurement.

    10. Practical Tips for Safe Use

    Reconstitution Accuracy – Use sterile water and follow manufacturer instructions to avoid contamination or incorrect dosing.

    Injection Technique – Rotate sites (abdomen, thigh) to prevent lipodystrophy.

    Monitoring – Regular blood tests for GH, IGF-1, glucose levels, and thyroid function can detect early imbalances.

    Lifestyle Factors – Adequate sleep, balanced nutrition, and moderate exercise amplify peptide benefits.

    11. Conclusion

    Sermorelin and Ipamorelin represent two distinct approaches to stimulating endogenous growth hormone production. Sermorelin offers a cost-effective, physiologically aligned option that requires multiple daily injections, while Ipamorelin delivers stronger, longer-lasting GH release with potentially fewer side effects but at a higher price. The choice between them should be guided by individual goals, tolerance for injection frequency, budget constraints, and the desire to minimize adverse reactions. Regardless of the peptide selected, diligent monitoring and adherence to safe administration practices are essential for maximizing therapeutic outcomes while minimizing risk.

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